adenosyl cobalamine
coenzyme B12
CAS: 13870-90-1
Molecular Formula: C72H100CoN18O17P
adenosyl cobalamine - Names and Identifiers
| Name | coenzyme B12 |
| Synonyms | COBAMIDE COBAMAMIDE Cobamamide COENZYME B12 coenzyme B12 DMBC COENZYME adenosyl cobalamine coenzyme B12 crystalline 5'-deoxyadenosylcobalamin 5'-DEOXYADENOSYLCOBALAMINE DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6- |
| CAS | 13870-90-1 |
| EINECS | 237-627-6 |
| InChI | InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2 |
adenosyl cobalamine - Physico-chemical Properties
| Molecular Formula | C72H100CoN18O17P |
| Molar Mass | 1579.58 |
| Water Solubility | 26g/L(24 ºC) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
| Appearance | Solid |
| Color | Red to Very Dark Red |
| Merck | 13,2476 |
| BRN | 4122932 |
| pKa | 3.5(at 25℃) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Physical and Chemical Properties | Red needle crystal or crystalline powder, odorless, tasteless, hygroscopic. Mp>300 ℃, mp210-220 ℃ (color depth), specific optical rotation [α]23656-59 ° (water), maximum absorption at 361nm wavelength. Soluble in water (1:80), ethanol (1:180) and acetic acid, insoluble in chloroform, ether and acetone. LD50 (rat, intraperitoneal) 1364 mg/kg. |
| Use | Vitamins |
adenosyl cobalamine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | GG3800000 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 2936260000 |
| Toxicity | LD50 oral in guinea pig: 5gm/kg |
adenosyl cobalamine - Reference Information
| Introduction | Adenosylcobalamin is one of the series of vitamin B12 products, the chemical name is: 5, 6-dimethylbenzimidazol-5'-deoxyadenine nucleoside cobalt amine is an octahedral cobalt amine complex. Cobamamide is a dark red crystalline and non-crystalline powder with strong hygroscopicity and easy decomposition when seen by light. Cobalamin adenosine is an important variety of vitamin B12 series products, which is an API and has important medical value. |
| Physiological function | Cobalamin adenosine is a similar substance of cyanocobalamin vitamin B12. It is an important coenzyme for cell synthesis of nucleotides and participates in methyl conversion in the body And folic acid metabolism, promote the reduction of methylfolic acid to tetrahydrofolic acid; it also participates in the tricarboxylic acid cycle, which is very important for the formation of lipoprotein in the nerve myelin, and can make the mercapto enzyme dry active state, so as to participate in a wide range of protein and fat metabolism. This product can promote the development and maturation of red blood cells, and is a necessary factor for the complete formation of nerve sheath spinal cord fibers and the maintenance of digestive system epithelial cell function. |
| uses | cobamamide is used for diseases caused by vitamin B12 deficiency, such as anemia during pregnancy and malnutrition anemia. It can also be used for adjuvant treatment of nutritional disorders and leukopenia caused by radiation and drugs. Biochemical research and tissue culture. Clinical drugs belong to the vitamin B family, which participate in the synthesis of nucleic acid, choline, methionine and the metabolism of fat and sugar in the body. They are clinically used to treat various megaloblastic anemia, dystrophic anemia and other diseases. |
| drug interaction | 1. it is not suitable to be mixed with chlorpromazine, vitamin c, vitamin k, etc. in the same container. 2. Chloramphenicol reduces its absorption. 3. cholestyramine can be combined with vitamin B12 to reduce its absorption. 4. Compatibility with glucose solution. 5. It cannot be used together with sodium p-aminosalicylate. |
| production method | cobalamin adenosine is a vitamin drug. it is made from the fermentation broth for producing chlortetracycline or streptomycin through hydrolysis, sodium cyanide, acidification and refining. |
Last Update：2024-04-09 21:54:55
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